Biomedical Research and Research Training

Published on AidPage by IDILOGIC on Jun 24, 2005

Purpose of this program:

To support basic biomedical research that is not targeted to specific diseases or disorders. Because scientific breakthroughs often originate from such untargeted stuides, NIGMS-funded work has contributed substantially to the tremendous progress that biomedical research has made in recent years. The Institute's training programs help provide the most critical element of good research: well-prepared scientists.

Possible uses and use restrictions...

NIGMS is organized into divisions and a center that support research and research training in basic biomedical science fields. One division has the specific mission of increasing the number of underrepresented minority biomedical and behavioral scientists. The key areas in which these divisions fund research are listed below. Division of Cell Biology and Biophysics: analytical and separation techniques; biomedical instrumentation; cell organization, motility, and division; lipid biochemistry; membrane structure and function; molecular biophysics; spectroscopic techniques; structural biology; and structural genomics. Division of Genetics and Developmental Biology: cell growth and differentiation; chromosome organization and mechanics; control of gene expression; control of the cell cycle; developmental genetics; extrachromosomal inheritance; mechanisms of mutagenesis; neurogenetics and the genetics of behavior; population genetics, evolution, and the genetics of complex traits; protein synthesis; replication, recombination, and repair of genes; and RNA processing and transcription. Division of Pharmacology, Physiology, and Biological Chemistry: anesthesiology; biochemistry; bioenergetics; bio-organic and bio-inorganic chemistry; biotechnology; glycoconjugates and glycobiology; medicinal chemistry; molecular immunobiology; pharmacogenetics; pharmacology and clinical pharmacology; physiology; synthetic chemistry; trauma and burn injury; and wound healing. Division of Minority Opportunities in Research: Minority Access to Research Careers Branch - supports research training at the undergraduate, graduate, and faculty levels; Minority Biomedical Research Support Branch - funds faculty-initiated research projects and student development grants at educational institutions with significant enrollments of underrepresented minority students. These grants help strengthen the institutions' biomedical research capabilities and develop the research competitiveness of the participating faculty. Center for Bioinformatics and Computational Biology: analysis of complex biological systems, biomedical software development, cell and molecular modeling and simulation, computational genomics, database design and enhancement, and high-throughput data analysis.

Who is eligible to apply...

NIGMS trainees must be U.S. citizens, non-citizen nationals, or permanent residents.

Eligible Applicant Categories:
Eligible Functional Categories:
Credentials/Documentation

Each applicant for research projects must present a research plan and furnish evidence that scientific competence, facilities, equipment, and supplies are appropriate to carry out the plan.

Note:This is a brief description of the credentials or documentation required prior to, or along with, an application for assistance.

About this section:

This section indicates who can apply to the Federal government for assistance and the criteria the potential applicant must satisfy. For example, individuals may be eligible for research grants, and the criteria to be satisfied may be that they have a professional or scientific degree, 3 years of research experience, and be a citizen of the United States. Universities, medical schools, hospitals, or State and local governments may also be eligible. Where State governments are eligible, the type of State agency will be indicated (State welfare agency or State agency on aging) and the criteria that they must satisfy.

Certain federal programs (e.g., the Pell Grant program which provides grants to students) involve intermediate levels of application processing, i.e., applications are transmitted through colleges or universities that are neither the direct applicant nor the ultimate beneficiary. For these programs, the criteria that the intermediaries must satisfy are also indicated, along with intermediaries who are not eligible.

How to apply...

Application Procedure:

Application forms (and information concerning the areas of science being supported) may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, Bethesda, MD 20892, and must be submitted to the Center for Scientific Review, National Institutes of Health, Bethesda, MD 20892 for assessment by a scientific review committee. The standard application forms, as furnished by PHS and required by 45 CFR, Part 92 for state and local governments, must be used for this program (these forms are available online at http://grants.nih.gov/grants/forms.htm). This program is subject to the provisions of 45 CFR, Part 92 for state and local governments and 45 CFR, Part 72 for other organizations, as appropriate.

Note: Each program will indicate whether applications are to be submitted to the Federal headquarters, regional or local office, or to a State or local government office.

Award Procedure:

All accepted applications are reviewed for scientific merit by an appropriate initial review group and by a national advisory council. National Research Service Award (NRSA) applications for the support of individual fellows and other applications requesting less than $50,000 direct costs per year are not reviewed by the council.) All approved applications compete for available funds on the basis of scientific merit and program emphasis.

Note: Grant payments may be made by a letter of credit, advance by Treasury check, or reimbursement by Treasury check. Awards may be made by the headquarters office directly to the applicant, an agency field office, a regional office, or by an authorized county office. The assistance may pass through the initial applicant for further distribution by intermediate level applicants to groups or individuals in the private sector.

Deadlines and process...

Deadlines

A list of NIGMS application receipt dates is available online at http://www.nigms.nih.gov/funding/appdate.html.

Note: When available, this section indicates the deadlines for applications to the funding agency which will be stated in terms of the date(s) or between what dates the application should be received. When not available, applicants should contact the funding agency for deadline information.

Range of Approval/Disapproval Time

Project Grants: about 9 months. NRSA: (institutional) 9-12 months, (individual) 6 months. Small Business Innovation Research (SBIR)/Small Business Technology Transfer Research (STTR): about 7-1/2 months.

Preapplication Coordination

Not applicable. This program is excluded from coverage under E.O. 12372.

Note: This section indicates whether any prior coordination or approval is required with governmental or nongovernmental units prior to the submission of a formal application to the federal funding agency.

Appeals

A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH Web site at http://grants.nih.gov/grants/guide/notice-files/not97-232.html.

Note: In some cases, there are no provisions for appeal. Where applicable, this section discusses appeal procedures or allowable rework time for resubmission of applications to be processed by the funding agency. Appeal procedures vary with individual programs and are either listed in this section or applicants are referred to appeal procedures documented in the relevant Code of Federal Regulations (CFR).

Renewals

Renewal grants are generally made prior to the expiration of any current award.

Note: In some instances, renewal procedures may be the same as for the application procedure, e.g., for projects of a non-continuing nature renewals will be treated as new, competing applications; for projects of an ongoing nature, renewals may be given annually.

Who can benefit...

Any nonprofit or for-profit organization, company, or institution engaged in biomedical research.

Beneficiaries
About this section:

This section lists the ultimate beneficiaries of a program, the criteria they must satisfy and who specifically is not eligible. The applicant and beneficiary will generally be the same for programs that provide assistance directly from a Federal agency. However, financial assistance that passes through State or local governments will have different applicants and beneficiaries since the assistance is transmitted to private sector beneficiaries who are not obligated to request or apply for the assistance.

What types of assistance...

Project Grants

The funding, for fixed or known periods, of specific projects. Project grants can include fellowships, scholarships, research grants, training grants, traineeships, experimental and demonstration grants, evaluation grants, planning grants, technical assistance grants, survey grants, and construction grants.

How much financial aid...

Range and Average of Financial Assistance

$20,000 to $7,500,000.

Note: This section lists the representative range (smallest to largest) of the amount of financial assistance available. These figures are based upon funds awarded in the past fiscal year and the current fiscal year to date. Also indicated is an approximate average amount of awards which were made in the past and current fiscal years.

Obligations

(Grants) FY 03 $1,760,207; FY 04 est $1,834,374; and FY 05 est $1,892,095.

Note: The dollar amounts listed in this section represent obligations for the past fiscal year (PY), estimates for the current fiscal year (CY), and estimates for the budget fiscal year (BY) as reported by the Federal agencies. Obligations for non-financial assistance programs indicate the administrative expenses involved in the operation of a program.

Account Identification

75-0897-0-1-552.

Note: Note: This 11-digit budget account identification code represents the account which funds a particular program. This code should be consistent with the code given for the program area as specified in Appendix III of the Budget of the United States Government.

Examples of funded projects...

NIGMS supports a wide array of grants supporting both research and training in areas described in paragraph 50. Examples of these grants are available in the Computer Retrieval of Information on Scientific Projects (CRISP) database at http://crisp.cit.nih.gov/.

About this section

This section indicates the different types of projects which have been funded in the past. Only projects funded under Project Grants or Direct Payments for Specified Use should be listed here. The examples give potential applicants an idea of the types of projects that may be accepted for funding. The agency should list at least five examples of the most recently funded projects.

Program accomplishments...

In fiscal year 2004, the Institute's budget was $1.9 billion. The vast majority of this money goes to fund grants to scientists at universities, medical schools, hospitals, and research institutions throughout the country. At any given time, NIGMS supports over 4,500 research grants--about 10 percent of the grants funded by NIH as a whole. NIGMS also supports approximately 45 percent of the predoctoral trainees and 28 percent of all the trainees who receive assistance from NIH.

Criteria for selecting proposals...

For an overview of NIGMS grant application and review, including funding policy, see http://www.nigms.nih.gov/research/grant_application_review.html.

Assistance considerations...

Length and Time Phasing of Assistance

Almost all awards are made for at least 1 year, with additional support (up to 4 more years) depending on the recommendation of the scientific review group, the national advisory council, successful annual performance, and availability of funds.

Formula and Matching Requirements

This program has no statutory formula or matching requirements.

Note:
A formula may be based on population, per capita income, and other statistical factors. Applicants are informed whether there are any matching requirements to be met when participating in the cost of a project. In general, the matching share represents that portion of the project costs not borne by the Federal government. Attachment F of OMB Circular No. A-102 (Office of Management and Budget) sets forth the criteria and procedures for the evaluation of matching share requirements which may be cash or in-kind contributions made by State and local governments or other agencies, institutions, private organizations, or individuals to satisfy matching requirements of Federal grants or loans.

Cash contributions represent the grantees' cash outlay, including the outlay of money contributed to the grantee by other public agencies, institutions, private organizations, or individuals. When authorized by Federal regulation, Federal funds received from other grants may be considered as the grantees' cash contribution.

In-kind contributions represent the value of noncash contributions provided by the grantee, other public agencies and institutions, private organizations or individuals. In-kind contributions may consist of charges for real property and equipment, and value of goods and services directly benefiting and specifically identifiable to the grant program. When authorized by Federal legislation, property purchased with Federal funds may be considered as grantees' in-kind contribution.

Maintenance of effort (MOE) is a requirement contained in certain legislation, regulations, or administrative policies stating that a grantee must maintain a specified level of financial effort in a specific area in order to receive Federal grant funds, and that the Federal grant funds may be used only to supplement, not supplant, the level of grantee funds.

Post assistance requirements...

Reports

Annual progress and selected financial status reports for continuing projects and final progress and financial reports on all projects upon conclusion are required. Recipients of NRSAs are required to file termination reports to ascertain compliance with the service and payback provisions.

Note: This section indicates whether program reports, expenditure reports, cash reports or performance monitoring are required by the Federal funding agency, and specifies at what time intervals (monthly, annually, etc.) this must be accomplished.

Audits

In accordance with the provisions of OMB Circular No. A-133 (Revised, June 24, 1997), "Audits of States, Local Governments, and Non-Profit Organizations," nonfederal entities that expend financial assistance of $300,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Audits of profit making organizations are addressed in 45 CFR Part 72 (Subpart C, Section 74.26). In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal government officials.

Note: This section discusses audits required by the Federal agency. The procedures and requirements for State and local governments and nonprofit entities are set forth in OMB Circular No. A-133. These requirements pertain to awards made within the respective State's fiscal year - not the Federal fiscal year, as some State and local governments may use the calendar year or other variation of time span designated as the fiscal year period, rather than that commonly known as the Federal fiscal year (from October 1st through September 30th).

Records

Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last financial status report for the report period.

Note: This section indicates the record retention requirements and the type of records the Federal agency may require. Not included are the normally imposed requirements of the General Accounting Office. For programs falling under the purview of OMB Circular No. A-102, record retention is set forth in Attachment C. For other programs, record retention is governed by the funding agency's requirements.

Regulations...

Authorization

Section 301 and Title IV of the Public Health Service Act, as amended

Note: This section lists the legal authority upon which a program is based (acts, amendments to acts, Public Law numbers, titles, sections, Statute Codes, citations to the U.S. Code, Executive Orders, Presidential Reorganization Plans, and Memoranda from an agency head).

Regulations, Guidelines, And Literature

45 CFR 16 Procedures of the Departmental Grant Appeals Board; 45 CFR 74; 45 CFR 92; NIH Extramural Programs brochure; miscellaneous program literature from Headquarters Office. Grants will be available under the authority of and administered in accordance with the NIH Grants Policy Statement and Federal regulations at 42 CFR 52 and 42 USC 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications. Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications.

Contact information...

Web Sites
Regional Or Local Office

Not applicable.

Note: This section lists the agency contact person, address and telephone number of the Federal Regional or Local Office(s) to be contacted for detailed information regarding a program such as: (1) current availability of funds and the likelihood of receiving assistance within a given period; (2) pre-application and application forms required; (3) whether a pre-application conference is recommended; (4) assistance available in preparation of applications; (5) whether funding decisions are made at the headquarters, regional or local level; (6) application renewal procedures (including continuations and supplementals) or appeal procedures for rejected applications; and (7) recently published program guidelines and material. However, for most federal programs, this section will instruct the reader to consult the so-called Appendix IV of the Catalog due to the large volume of Regional and Local Office Contacts for most agencies. This information is provided in Additional Contact Information (see below).

Headquarters Office

National Institute of General Medical Sciences, National Institutes of Health, 45 Center Drive MSC 6200, Bethesda, MD 20892-6200, Division Contacts: Division of Cell Biology and Biophysics, Dr. James C. Cassatt, director, 301-594-0828; Division of Genetics and Developmental Biology, Dr. Judith H. Greenberg, director, 301-594-0943; Division of Pharmacology, Physiology, and Biological Chemistry, Dr. Michael E. Rogers, director, 301-594-3827; Division of Minority Opportunities in Research, Dr. Clifton A. Poodry, director, 301-594-3900; Division of Extramural Activities, Dr. Ann Hagan, director, 301-594-3910; Center for Bioinformatics and Computational Biology Dr. Eric Jakobsson, Director, 301-594-5236; Grants Management Office: 301-594-5135.

Note: This section lists names and addresses of the office at the headquarters level with direct operational responsibility for managing a program. A telephone number is provided in cases where a Regional or Local Office is not normally able to answer detailed inquiries concerning a program. Also listed are the name(s) and telephone number(s) of the information contact person(s) who can provide additional program information to applicants.

Additional Contact Information (Appendix IV)

Due to the large volume of regional and local office contacts for most agencies, full contact information is also provided separately here in a PDF format: